Licensing

Licensing Opportunities
For Your Project’s Success

IONTAS wishes to see the benefits of its technologies exploited as widely as possible. To this end we have a range of technologies available for licensing arising from research at our facilities.
Where technologies are licenced to third parties, we offer a range of support to ensure the effective operation of transferred technologies into our partners facilities. Furthermore, consultancy can be offered to support specific requirements or further development of our platforms.

Currently IONTAS offers three licencing opportunities:

  • Triple Vector
  • Naïve Phage Display Libraries
  • Mammalian Display

This technology facilitates the conversion antibody fragments into full length IgG or Fc fusion proteins, typically a bottleneck in antibody discovery. Moreover, for some antibody fragments the conversion to Fc fusion proteins result in loss of activity. To circumvent these drawbacks, the triple vector technology comprises a vector that contains the elements necessary to produce soluble antibody fragments in bacteria, and mammalian cells. Ultimately the selection of immunological effector function bearing bivalent molecules, bypassing the cloning into mammalian expression vectors, will accelerate the drug discovery process.

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Designed to meet our Partners needs, these libraries be based around naïve human scFv or Fab repertoires or llama VHH repertoires. As with mammalian display, training and support are offered to ensure the libraries are functional and successful in our Partner facilities

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An antibody discovery platform that generates vast libraries of fully human IgG on the surface of a mammalian cell. The platform is designed so one antibody is expressed per cell. This allows for screening of IgG by using FACS (allowing the full library to be screened) for function and presentation levels. Subsequent work has shown that presentation level strongly correlates to developability. The platform can be transferred toa Partners facility and training/support can be offered at either Partner sites or within IONTAS’s facilities. The licencing of mammalian display also encompasses improvements to the platform and we welcome collaborative developments to address specific need of our partners.

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